Reaction Details |
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Target | Bromodomain-containing protein 4 [342-460]/[42-168] |
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Ligand | BDBM111094 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Amplified Luminescent Proximity Homogeneous Assay (ALPHA) |
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Temperature | 298.15±n/a K |
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IC50 | 11200±n/a nM |
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Comments | extracted |
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Citation | Vankayalapati, H; Yoshioka, M; Strovel, JW; Padia, JK Methods and compositions for inhibition of bromodomain-containing proteins US Patent US9695179 Publication Date 7/4/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 4 [342-460]/[42-168] |
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Name: | Bromodomain-containing protein 4 [342-460]/[42-168] |
Synonyms: | BRD4-BD1-BD2 |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 3 components. |
Component 1 |
Name: | Bromodomain-containing protein 4 [42-168] |
Synonyms: | BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 15054.68 |
Organism: | Homo sapiens (Human) |
Description: | O60885[42-168] |
Residue: | 127 |
Sequence: | STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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Component 2 |
Name: | Bromodomain-containing protein 4 [342-460] |
Synonyms: | BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 13783.81 |
Organism: | Homo sapiens (Human) |
Description: | a.a. 342-460 (BRD4-BD2) |
Residue: | 119 |
Sequence: | PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMS
TIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
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BDBM111094 |
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n/a |
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Name | BDBM111094 |
Synonyms: | US9695179, 90 |
Type | Small organic molecule |
Emp. Form. | C28H21N3O3 |
Mol. Mass. | 447.4846 |
SMILES | Cc1noc(C)c1-c1ccc2[nH]c(=O)c(C(=O)\C=C\c3ccccc3)c(-c3cccnc3)c2c1 |
Structure |
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