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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 2 | ||
| Ligand | BDBM277100 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Biological Assays | ||
| IC50 | 7400±n/a nM | ||
| Citation |  Arasappan, A; Bungard, CJ; Frie, JL; Han, Y; Hoyt, SB; Manley, PJ; Meissner, RS; Perkins, JJ; Sebhat, IK; Wilkening, RR; Leavitt, KJ Tetrahydronaphthyridine derivatives as mGluR2-negative allosteric modulators, compositions, and their use US Patent US10072003 Publication Date 9/11/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 2 | |||
| Name: | Metabotropic glutamate receptor 2 | ||
| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 95584.88 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14416 | ||
| Residue: | 872 | ||
| Sequence: |
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| BDBM277100 | |||
| n/a | |||
| Name | BDBM277100 | ||
| Synonyms: | 7-[(1-tert-butyl-1H-1,2,3- triazol-5-yl)methyl]-4-(4- chloro-2,6- difluorophenyl)-5,6,7,8- tetrahydro-1,7- naphthyridine-2- carboxamide | US10072003, Example 1-17 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H23ClF2N6O | ||
| Mol. Mass. | 460.907 | ||
| SMILES | CC(C)(C)n1nncc1CN1CCc2c(C1)nc(cc2-c1c(F)cc(Cl)cc1F)C(N)=O |(-1.57,.85,;-3.06,.45,;-3.46,-1.04,;-1.97,-.64,;-4.15,1.54,;-5.61,1.06,;-6.52,2.31,;-5.61,3.56,;-4.15,3.08,;-2.82,3.85,;-1.48,3.08,;-1.48,1.54,;-.15,.77,;1.18,1.54,;1.18,3.08,;-.15,3.85,;2.52,3.85,;3.85,3.08,;3.85,1.54,;2.52,.77,;2.52,-.77,;3.85,-1.54,;5.19,-.77,;3.85,-3.08,;2.52,-3.85,;2.52,-5.39,;1.18,-3.08,;1.18,-1.54,;-.15,-.77,;5.19,3.85,;6.52,3.08,;5.19,5.39,)| | ||
| Structure | 
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