| Reaction Details |
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 | Report a problem with these data |
| Target | cholinergic receptor, nicotinic, alpha 1 (Muscle) isoform X1 |
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| Ligand | BDBM50063218 |
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| Substrate/Competitor | n/a |
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| Ki | 14±n/a nM |
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| Comments | PDSP_785 |
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| Citation |  Avalos, M; Parker, MJ; Maddox, FN; Carroll, FI; Luetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther302:1246-52 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| cholinergic receptor, nicotinic, alpha 1 (Muscle) isoform X1 |
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| Name: | cholinergic receptor, nicotinic, alpha 1 (Muscle) isoform X1 |
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| Synonyms: | Cholinergic, Nicotinic Alpha3Beta2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51980.65 |
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| Organism: | Xenopus |
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| Description: | Cholinergic, Nicotinic Alpha3Beta2 0 Xenopus::F6RLM5 |
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| Residue: | 457 |
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| Sequence: | MDYTASCLIFFFIAAGPVFSSDHETRLIGDLFANYNKVVRPVETYKDQVVVTVGLQLIQL
INVDEVNQIVSTNIRLKQQWVDVNLKWDPAKYGGVKKLRIPSSEVWCPDLVLYNNADGDF
AISKDTKILLEHTGKITWTPPAIFKSYCEIIVTHFPFDQQNCSMKFGTWTYDGTLVVINP
DRDRPDLSNFMASGEWMMKDYRCWKHWVYYTCCPDKPYLDITYHFVLQRLPLYFIVNVII
PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF
TMVFVIASIIITVIVINTHHRSPSTHTMPPWVRKIFIDTIPNIMFFSTMKRPSQEKQPQT
TFAEEMDISDISGKLGPAAVTYQSPALKNPDVKSAIEGIKYIAETMKSDQESNKASEEWK
FVAMVLDHILLAVFMTVCVIGTLAVFAGRIIEMNMQD
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| BDBM50063218 |
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| n/a |
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| Name | BDBM50063218 |
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| Synonyms: | (R)-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | 2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane(+/-) epibatidine | Epibatidine | rac-(2R)-2-(6-chloropyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane |
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| Type | Small organic molecule |
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| Emp. Form. | C11H13ClN2 |
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| Mol. Mass. | 208.687 |
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| SMILES | Clc1ccc(cn1)[C@H]1CC2CCC1N2 |THB:4:7:13:11.10| |
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| Structure | 
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