Ki Summary

Reaction Details

Report a problem with these data

Target

Phosphoethanolamine N-methyltransferase 1

Ligand

BDBM28422

Substrate/Competitor

n/a

Meas. Tech.

Calorimetric (ITC) Assay

7.5±0

Temperature

293.15±0 K

1.66e+4± 1.7e+3 nM

Citation

Lee, SG; Haakenson, W; McCarter, JP; Williams, DJ; Hresko, MC; Jez, JM Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus. J Biol Chem286:38060-8 (2011) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Phosphoethanolamine N-methyltransferase 1

Name:

Phosphoethanolamine N-methyltransferase 1

Synonyms:

Phosphoehtnaolamine Methyltransferases 1 (PMT1)

Type:

Enzyme

Mol. Mass.:

53531.36

Organism:

Caenorhabditis elegans

Description:

Q86NB3

Residue:

475

Sequence:

MSTDQQSSVEDQTVAMVNVRRANFKSFWDKYSDKPDTNSMMLNHSAEELESSDRADILAS
LPLLHNKDVVDIGAGIGRFTTVLAETARWVLSTDFIDSFIKKNQERNAHLGNINYQVGDA
VGLKMESNSVDLVFTNWLMMYLSDEETVEFIFNCMRWLRSHGIVHLRESCSEPSTGRSKA
KSMHDTANANPTHYRFSSLYINLLRAIRYRDVDNKLWRFNVQWSCSVPTYIKRSNNWRQV
HWLAEKVPAEDGAKGTSFNELVELIKNTWQNEQEAWDAKLDDEKYVWTDKVFSSALTSLP
SNSTFFLYTPRTVSPYCHINAHTLAETFNANVWNTEIIPEYYRTSLTKSNNLKDQRVRFG
WNQSLTDSVTYWQQKDALFDVFVATEFLSTVDDETIRQLPNVMSDGAKFITLEPVDEVNE
AEMKQRIQELGYTLKSFTDVTDQCIEAQEQYFKDHEQLRDEKVIRKNWVLLELTH

BDBM28422

n/a

Name

BDBM28422

Synonyms:

(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(methyl)sulfanylium)butanoate | AdoMet | S-Adenosylmethionine | S-adenosyl-L-[carboxy-14C]methionine | [14COOH]AdoMet

Type

radiolabeled substrate

Emp. Form.

C15H22N6O5S

Mol. Mass.

398.437

SMILES

C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12

Structure