| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin L2 |
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| Ligand | BDBM93444 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Activity Assay |
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| pH | 5.5±0 |
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| Temperature | 300.15±0 K |
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| IC50 | 8e+2± 5e+1 nM |
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| Citation |  Alvim, J; Severino, RP; Marques, EF; Martinelli, AM; Vieira, PC; Fernandes, JB; da Silva, MF; Corrêa, AG Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors. J Comb Chem12:687-95 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Cathepsin L2 |
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| Name: | Cathepsin L2 |
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| Synonyms: | CATL2 | CATL2_HUMAN | CTSL2 | CTSU | CTSV | Cathepsin U | Cathepsin V |
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| Type: | Enzyme |
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| Mol. Mass.: | 37341.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60911 |
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| Residue: | 334 |
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| Sequence: | MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
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| BDBM93444 |
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| n/a |
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| Name | BDBM93444 |
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| Synonyms: | Flavonid, 6[3,1] |
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| Type | Small molecule |
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| Emp. Form. | C16H11FO3 |
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| Mol. Mass. | 270.2551 |
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| SMILES | COc1ccc(cc1)-c1cc(=O)c2cc(F)ccc2o1 |
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| Structure | 
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