Reaction Details |
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Target | Sentrin-specific protease 8 |
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Ligand | BDBM71225 |
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Substrate/Competitor | n/a |
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IC50 | 2930±156 nM |
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Citation | PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay(2012)[AID] |
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More Info.: | Get all data from this article |
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Sentrin-specific protease 8 |
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Name: | Sentrin-specific protease 8 |
Synonyms: | DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 24104.52 |
Organism: | Homo sapiens (Human) |
Description: | gi_262118306 |
Residue: | 212 |
Sequence: | MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQ
FIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDS
HSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFR
QQTESLLQLLTPAYITKKRGEWKDLITTLAKK
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BDBM71225 |
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n/a |
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Name | BDBM71225 |
Synonyms: | CMLD004221 | MLS001045877 | SMR000452773 | [2-(4-hydroxybutyl)-3-(4-methoxy-4-oxobutyl)-7-methyl-6,8-dioxo-5-phenylisoquinolin-7-yl] cyclopentanecarboxylate | [3-(4-methoxy-4-oxidanylidene-butyl)-7-methyl-2-(4-oxidanylbutyl)-6,8-bis(oxidanylidene)-5-phenyl-isoquinolin-7-yl] cyclopentanecarboxylate | cid_16745577 | cyclopentanecarboxylic acid [2-(4-hydroxybutyl)-3-(4-methoxy-4-oxobutyl)-7-methyl-6,8-dioxo-5-phenyl-7-isoquinolinyl] ester | cyclopentanecarboxylic acid [2-(4-hydroxybutyl)-6,8-diketo-3-(4-keto-4-methoxy-butyl)-7-methyl-5-phenyl-7-isoquinolyl] ester |
Type | Small organic molecule |
Emp. Form. | C31H37NO7 |
Mol. Mass. | 535.628 |
SMILES | COC(=O)CCCC1=CC2=C(C(=O)C(C)(OC(=O)C3CCCC3)C(=O)C2=CN1CCCCO)c1ccccc1 |c:27,t:7,9| |
Structure |
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