| Reaction Details |
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 | Report a problem with these data |
| Target | Sentrin-specific protease 8 |
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| Ligand | BDBM93580 |
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| Substrate/Competitor | n/a |
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| IC50 | 577±50 nM |
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| Citation |  PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay(2012)[AID] |
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| More Info.: | Get all data from this article |
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| Sentrin-specific protease 8 |
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| Name: | Sentrin-specific protease 8 |
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| Synonyms: | DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 24104.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_262118306 |
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| Residue: | 212 |
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| Sequence: | MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQ
FIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDS
HSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFR
QQTESLLQLLTPAYITKKRGEWKDLITTLAKK
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| BDBM93580 |
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| n/a |
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| Name | BDBM93580 |
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| Synonyms: | 5-amino-N'-(4-chlorobenzylidene)-4-oxo-3-phenyl-3,4-dihydrothieno[3,4-d]pyridazine-1-carbohydrazide | 5-amino-N-[(E)-(4-chlorobenzylidene)amino]-4-keto-3-phenyl-thieno[3,4-d]pyridazine-1-carboxamide | 5-amino-N-[(E)-(4-chlorophenyl)methylideneamino]-4-oxo-3-phenyl-1-thieno[3,4-d]pyridazinecarboxamide | 5-amino-N-[(E)-(4-chlorophenyl)methylideneamino]-4-oxo-3-phenylthieno[3,4-d]pyridazine-1-carboxamide | 5-azanyl-N-[(E)-(4-chlorophenyl)methylideneamino]-4-oxidanylidene-3-phenyl-thieno[3,4-d]pyridazine-1-carboxamide | MLS000544578 | SMR000164095 | cid_49849259 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H14ClN5O2S |
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| Mol. Mass. | 423.875 |
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| SMILES | Nc1scc2c(nn(-c3ccccc3)c(=O)c12)C(=O)N\N=C\c1ccc(Cl)cc1 |
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| Structure | 
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