Reaction Details |
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Target | Sentrin-specific protease 8 |
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Ligand | BDBM42207 |
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Substrate/Competitor | n/a |
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IC50 | 543±69 nM |
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Citation | PubChem, PC Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate PubChem Bioassay(2012)[AID] |
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More Info.: | Get all data from this article |
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Sentrin-specific protease 8 |
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Name: | Sentrin-specific protease 8 |
Synonyms: | DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 24104.52 |
Organism: | Homo sapiens (Human) |
Description: | gi_262118306 |
Residue: | 212 |
Sequence: | MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQ
FIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDS
HSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFR
QQTESLLQLLTPAYITKKRGEWKDLITTLAKK
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BDBM42207 |
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n/a |
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Name | BDBM42207 |
Synonyms: | (8S,8aR,11aS,11bS)-8-Acetyl-10-(4-methoxy-phenyl)-8,8a,11a,11b-tetrahydro-pyrrolo[3',4':3,4]pyrrolo[ 2,1-a]isoquinoline-9,11-dione | MLS000554181 | SMR000146498 | cid_6356140 |
Type | Small organic molecule |
Emp. Form. | C23H20N2O4 |
Mol. Mass. | 388.4159 |
SMILES | [H][C@]12[C@H](N3C=Cc4ccccc4[C@]3([H])[C@@]1([H])C(=O)N(C2=O)c1ccc(OC)cc1)C(C)=O |c:4| |
Structure |
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