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TargetTumor necrosis factor receptor superfamily member 10B
LigandBDBM95913
Substrate/Competitorn/a
EC50 10400±n/a nM
Citation PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay(2013)[AID]
More Info.:Get all data from this article
 
Tumor necrosis factor receptor superfamily member 10B
Name:Tumor necrosis factor receptor superfamily member 10B
Synonyms:DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]
Type:Enzyme Catalytic Domain
Mol. Mass.:47869.76
Organism:Homo sapiens (Human)
Description:gi_224494019
Residue:440
Sequence:
MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQD
LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD
SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH
KESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKV
LPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGV
NMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRK
LGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIED
HLLSSGKFMYLEGNADSAMS
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BDBM95913
n/a
NameBDBM95913
Synonyms:5-N-[3-methoxy-5-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1H-imidazole-4,5-dicarboxamide | MLS002391232 | N'-[3-methoxy-5-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1H-imidazole-4,5-dicarboxamide | N5-[3-methoxy-5-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1H-imidazole-4,5-dicarboxamide | N5-[3-methoxy-5-[oxo-[3-(trifluoromethyl)anilino]methyl]phenyl]-1H-imidazole-4,5-dicarboxamide | SMR001355231 | cid_44142674
TypeSmall organic molecule
Emp. Form.C20H16F3N5O4
Mol. Mass.447.3673
SMILESCOc1cc(NC(=O)c2[nH]cnc2C(N)=O)cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Structure
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