| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor receptor superfamily member 10B |
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| Ligand | BDBM95914 |
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| Substrate/Competitor | n/a |
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| EC50 | 11100±n/a nM |
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| Citation |  PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay(2013)[AID] |
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| More Info.: | Get all data from this article |
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| Tumor necrosis factor receptor superfamily member 10B |
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| Name: | Tumor necrosis factor receptor superfamily member 10B |
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| Synonyms: | DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47869.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_224494019 |
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| Residue: | 440 |
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| Sequence: | MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQD
LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD
SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH
KESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKV
LPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGV
NMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRK
LGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIED
HLLSSGKFMYLEGNADSAMS
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| BDBM95914 |
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| n/a |
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| Name | BDBM95914 |
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| Synonyms: | 4-(3,5-dimethyl-1-pyrazolyl)-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]benzamide | 4-(3,5-dimethylpyrazol-1-yl)-N-(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)benzamide | 4-(3,5-dimethylpyrazol-1-yl)-N-(4-methyl-3-morpholin-4-ylsulfonylphenyl)benzamide | 4-(3,5-dimethylpyrazol-1-yl)-N-(4-methyl-3-morpholinosulfonyl-phenyl)benzamide | MLS000773648 | SMR000364351 | cid_4162856 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N4O4S |
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| Mol. Mass. | 454.542 |
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| SMILES | Cc1cc(C)n(n1)-c1ccc(cc1)C(=O)Nc1ccc(C)c(c1)S(=O)(=O)N1CCOCC1 |
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| Structure | 
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