| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor receptor superfamily member 10B |
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| Ligand | BDBM96015 |
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| Substrate/Competitor | n/a |
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| EC50 | 12200±n/a nM |
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| Citation |  PubChem, PC Dose Response confirmation of uHTS hits for a small molecule Caspase-8 TRAIL sensitizers in a luminescence panel assay PubChem Bioassay(2013)[AID] |
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| More Info.: | Get all data from this article |
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| Tumor necrosis factor receptor superfamily member 10B |
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| Name: | Tumor necrosis factor receptor superfamily member 10B |
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| Synonyms: | DR5 | KILLER | TNFRSF10B | TR10B_HUMAN | TRAILR2 | TRICK2 | ZTNFR9 | tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47869.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_224494019 |
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| Residue: | 440 |
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| Sequence: | MEQRGQNAPAASGARKRHGPGPREARGARPGPRVPKTLVLVVAAVLLLVSAESALITQQD
LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD
SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH
KESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKV
LPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQEPAEPTGV
NMLSPGESEHLLEPAEAERSQRRRLLVPANEGDPTETLRQCFDDFADLVPFDSWEPLMRK
LGLMDNEIKVAKAEAAGHRDTLYTMLIKWVNKTGRDASVHTLLDALETLGERLAKQKIED
HLLSSGKFMYLEGNADSAMS
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| BDBM96015 |
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| n/a |
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| Name | BDBM96015 |
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| Synonyms: | 3-(4-fluorophenyl)-6-(2-thienyl)pyrazolo[1,5-a]pyrimidin-7-amine | 3-(4-fluorophenyl)-6-thiophen-2-yl-7-pyrazolo[1,5-a]pyrimidinamine | 3-(4-fluorophenyl)-6-thiophen-2-yl-pyrazolo[1,5-a]pyrimidin-7-amine | 3-(4-fluorophenyl)-6-thiophen-2-ylpyrazolo[1,5-a]pyrimidin-7-amine | MLS001165963 | SMR000550229 | [3-(4-fluorophenyl)-6-(2-thienyl)pyrazolo[1,5-a]pyrimidin-7-yl]amine | cid_1474449 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11FN4S |
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| Mol. Mass. | 310.349 |
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| SMILES | Nc1c(cnc2c(cnn12)-c1ccc(F)cc1)-c1cccs1 |
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| Structure | 
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