| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin/Hypocretin receptor type 1 |
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| Ligand | BDBM97406 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLIPR Ca2+ Flux Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 3651±0 nM |
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| Comments | extracted |
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| Citation |  Kuduk, SD; Skudlarek, JW 2-pyridyloxy-4-nitrile orexin receptor antagonists US Patent US20130102619 Publication Date 4/25/2013 |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin/Hypocretin receptor type 1 |
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| Name: | Orexin/Hypocretin receptor type 1 |
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| Synonyms: | Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R |
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| Type: | Protein |
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| Mol. Mass.: | 46817.55 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P56718 |
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| Residue: | 416 |
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| Sequence: | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQA
AVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFR
KLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
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|
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| BDBM97406 |
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| n/a |
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| Name | BDBM97406 |
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| Synonyms: | Orexin receptor antagonist 1 | US20130102619, 1 |
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| Type | Small molecule |
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| Emp. Form. | C21H20N6O2 |
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| Mol. Mass. | 388.4225 |
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| SMILES | C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cc(ccn1)C#N |r| |
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| Structure | 
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