Reaction Details |
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Target | Probable nicotinate-nucleotide adenylyltransferase |
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Ligand | BDBM98122 |
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Substrate/Competitor | n/a |
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Meas. Tech. | NaMNAT HPLC Enzyme Assay |
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pH | 7.5±0 |
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Temperature | 273.15±0 K |
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IC50 | 13300±0.0 nM |
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Citation | Moro, WB; Yang, Z; Kane, TA; Zhou, Q; Harville, S; Brouillette, CG; Brouillette, WJ SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. J Comb Chem11:617-25 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Probable nicotinate-nucleotide adenylyltransferase |
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Name: | Probable nicotinate-nucleotide adenylyltransferase |
Synonyms: | BAMEG_4595 | Deamido-NAD(+) diphosphorylase | Deamido-NAD(+) pyrophosphorylase | NADD_BACAC | Nicotinate mononucleotide adenylyltransferase | Nicotinate-nucleotide adenylyltransferase | Nicotinate-nucleotide adenylyltransferase (NadD) | Nicotinic acid mononucleotide adenylyltransferase (NaMNAT) | nadD |
Type: | Enzyme |
Mol. Mass.: | 21955.08 |
Organism: | Bacillus anthracis |
Description: | C3L5T6 |
Residue: | 189 |
Sequence: | MRKIGIIGGTFDPPHYGHLLIANEVYHALNLEEVWFLPNQIPPHKQGRNITSVESRLQML
ELATEAEEHFSICLEELSRKGPSYTYDTMLQLTKKYPDVQFHFIIGGDMVEYLPKWYNIE
ALLDLVTFVGVARPGYKLRTPYPITTVEIPEFAVSSSLLRERYKEKKTCKYLLPEKVQVY
IERNGLYES
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BDBM98122 |
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n/a |
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Name | BDBM98122 |
Synonyms: | 1-(4-nitrophenyl)-3-[4-[[2-(trifluoromethyl)phenyl]sulfonylamino]phenyl]urea | Compound ID 7{1,11} |
Type | Small organic molecule |
Emp. Form. | C20H15F3N4O5S |
Mol. Mass. | 480.417 |
SMILES | [O-][N+](=O)c1ccc(NC(=O)Nc2ccc(NS(=O)(=O)c3ccccc3C(F)(F)F)cc2)cc1 |
Structure |
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