Reaction Details |
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Target | Glutaminyl-peptide cyclotransferase |
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Ligand | BDBM102919 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Spectrophotometric Assay |
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Ki | 346±n/a nM |
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IC50 | 3.99e+3±n/a nM |
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Citation | Heiser, U; Ramsbeck, D; Hoffmann, T; Boehme, L Inhibitors US Patent US8541596 Publication Date 9/24/2013 |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminyl-peptide cyclotransferase |
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Name: | Glutaminyl-peptide cyclotransferase |
Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 40877.05 |
Organism: | Homo sapiens (Human) |
Description: | Q16769 |
Residue: | 361 |
Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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BDBM102919 |
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n/a |
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Name | BDBM102919 |
Synonyms: | US8541596, 20 |
Type | Small organic molecule |
Emp. Form. | C23H23N3 |
Mol. Mass. | 341.4488 |
SMILES | Cc1ccc(CN(Cc2ccc(C)cc2)c2ccc3nc[nH]c3c2)cc1 |
Structure |
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