Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50199914 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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pH | 7.8±0 |
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Temperature | 298.15±0 K |
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Ki | 139±0.0 nM |
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Citation | Dolle, RE; Le Bourdonnec, B; Goodman, AJ Opioid antagonists US Patent US8580788 Publication Date 11/12/2013 |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50199914 |
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n/a |
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Name | BDBM50199914 |
Synonyms: | 3-((7R,8R,9alphaR)-2-benzyl-7,8-dimethyl-octahydro-1H-pyrido-[1,2-R]pyrazin-8-yl)phenol | CHEMBL376690 | US8580788, 60 |
Type | Small organic molecule |
Emp. Form. | C23H30N2O |
Mol. Mass. | 350.4971 |
SMILES | C[C@H]1CN2CCN(Cc3ccccc3)C[C@H]2C[C@@]1(C)c1cccc(O)c1 |r| |
Structure |
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