Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-3

Ligand

BDBM106924

Substrate/Competitor

n/a

Meas. Tech.

ATP Depletion Assay

7.5±0

IC50

1±n/a nM

Citation

Burger, MT; Han, W; Lan, J; Nishiguchi, G Kinase inhibitors and methods of their use US Patent US8592455 Publication Date 11/26/2013

More Info.:

Get all data from this article, Solution Info, Assay Method

Serine/threonine-protein kinase pim-3

Name:

Serine/threonine-protein kinase pim-3

Synonyms:

PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)

Type:

Protein

Mol. Mass.:

35888.19

Organism:

Homo sapiens (Human)

Description:

Q86V86

Residue:

326

Sequence:

MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL

BDBM106924

n/a

Name

BDBM106924

Synonyms:

US8592455, 124

Type

Small organic molecule

Emp. Form.

C23H21F3N4O2

Mol. Mass.

442.4336

SMILES

N[C@H]1CCC[C@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)ccc(O)c1F |r,wU:5.7,1.0,(-6,2.69,;-4.67,1.92,;-3.33,2.69,;-2,1.92,;-2,.38,;-3.33,-.39,;-4.67,.38,;-3.33,-1.93,;-4.67,-2.7,;-4.67,-4.24,;-3.33,-5.01,;-2,-4.24,;-2,-2.7,;-.67,-1.93,;.67,-2.7,;.67,-4.24,;2,-1.93,;3.33,-2.69,;4.67,-1.93,;4.67,-.39,;6,.38,;3.33,.38,;2,-.39,;3.33,1.92,;2,2.69,;.67,1.92,;2,4.23,;3.33,5,;4.67,4.23,;6,5.01,;4.67,2.69,;6,1.92,)|

Structure