| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor protein-tyrosine kinase |
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| Ligand | BDBM108059 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Z-LYTE biochemical assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.37e+3±n/a nM |
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| Comments | extracted |
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| Citation |  Jia, Y; Zhang, J; Feng, J; Xu, F; Pan, H; Xu, W Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents. Chem Biol Drug Des83:306-16 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor protein-tyrosine kinase |
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| Name: | Receptor protein-tyrosine kinase |
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| Synonyms: | EGFR | Q504U8_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 120695.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q504U8 |
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| Residue: | 1091 |
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| Sequence: | MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG
KSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKY
SFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEF
KDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFL
LIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISG
NKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVS
CRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY
IDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPS
IATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLR
ILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV
MASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGM
NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES
ILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM
IMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEE
DMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSF
LQRYSSDPTGALTEDSIDDTFLPVPGEWLVWKQSCSSTSSTHSAAASLQCPSQVLPPASP
EGETVADLQTQ
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| BDBM108059 |
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| n/a |
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| Name | BDBM108059 |
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| Synonyms: | N-carbamimidoyl-4-((4-((2,3-dimethyl-2H-indazole- 6-yl)(methyl)amino)pyrimidin-2-yl)amino) benzenesulfonamide (P2g) |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N9O2S |
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| Mol. Mass. | 465.531 |
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| SMILES | CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(cc2)S(=O)(=O)NC(N)=N)n1 |
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| Structure | 
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