Ki Summary

Reaction Details

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Target

Carboxypeptidase B2

Ligand

BDBM109239

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Inhibition Assay

IC50

8.8±n/a nM

Citation

Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent US8609710 Publication Date 12/17/2013

More Info.:

Get all data from this article, Assay Method

Carboxypeptidase B2

Name:

Carboxypeptidase B2

Synonyms:

Type:

Enzyme

Mol. Mass.:

48432.74

Organism:

Homo sapiens (Human)

Description:

Q96IY4

Residue:

423

Sequence:

MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV

BDBM109239

n/a

Name

BDBM109239

Synonyms:

US8609710, 3

Type

Small organic molecule

Emp. Form.

C17H29N3O2

Mol. Mass.

307.4311

SMILES

CC[C@H]1CC[C@@H](CC1)n1cnc(CC(CCCN)C(O)=O)c1 |r,wU:5.8,wD:2.1,(-4.94,5.34,;-3.45,4.94,;-3.05,3.45,;-4.14,2.36,;-3.74,.87,;-2.26,.48,;-1.17,1.57,;-1.57,3.05,;-1.86,-1.01,;-2.76,-2.26,;-1.86,-3.5,;-.39,-3.03,;.94,-3.8,;2.27,-3.03,;2.27,-1.49,;3.61,-.72,;3.61,.82,;4.94,1.59,;3.61,-3.8,;3.61,-5.34,;4.94,-3.03,;-.39,-1.49,)|

Structure