Ki Summary

Reaction Details

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Target

Carboxypeptidase B2

Ligand

BDBM109250

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Inhibition Assay

IC50

13±n/a nM

Citation

Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent US8609710 Publication Date 12/17/2013

More Info.:

Get all data from this article, Assay Method

Carboxypeptidase B2

Name:

Carboxypeptidase B2

Synonyms:

Type:

Enzyme

Mol. Mass.:

48432.74

Organism:

Homo sapiens (Human)

Description:

Q96IY4

Residue:

423

Sequence:

MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV

BDBM109250

n/a

Name

BDBM109250

Synonyms:

US8609710, 14

Type

Small organic molecule

Emp. Form.

C21H29N3O3

Mol. Mass.

371.4733

SMILES

NCCCC(Cc1cn(cn1)[C@H]1CC[C@@H](CC1)Oc1ccccc1)C(O)=O |r,wU:11.11,wD:14.18,(6.03,-.04,;4.7,-.81,;4.7,-2.35,;3.36,-3.12,;3.36,-4.66,;2.03,-5.43,;.69,-4.66,;.69,-3.12,;-.77,-2.64,;-1.67,-3.89,;-.77,-5.14,;-1.17,-1.16,;-2.66,-.76,;-3.05,.73,;-1.97,1.82,;-.48,1.42,;-.08,-.07,;-2.36,3.31,;-3.45,4.39,;-3.05,5.88,;-4.14,6.97,;-5.63,6.57,;-6.03,5.08,;-4.94,4,;4.7,-5.43,;4.7,-6.97,;6.03,-4.66,)|

Structure