Ki Summary

Reaction Details

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Target

Carboxypeptidase B2

Ligand

BDBM109260

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Inhibition Assay

IC50

10±n/a nM

Citation

Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent US8609710 Publication Date 12/17/2013

More Info.:

Get all data from this article, Assay Method

Carboxypeptidase B2

Name:

Carboxypeptidase B2

Synonyms:

Type:

Enzyme

Mol. Mass.:

48432.74

Organism:

Homo sapiens (Human)

Description:

Q96IY4

Residue:

423

Sequence:

MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV

BDBM109260

n/a

Name

BDBM109260

Synonyms:

US8609710, 36

Type

Small organic molecule

Emp. Form.

C18H31N3O2

Mol. Mass.

321.4576

SMILES

CCC(CN)CC(Cc1cn(cn1)[C@H]1CC[C@H](C)CC1)C(O)=O |r,wU:13.13,wD:16.17,(4.8,-.52,;3.47,-1.29,;2.14,-.52,;2.14,1.02,;3.47,1.79,;.8,-1.29,;.8,-2.83,;-.53,-3.6,;-1.86,-2.83,;-1.86,-1.29,;-3.33,-.81,;-4.23,-2.06,;-3.33,-3.3,;-3.73,.68,;-5.22,1.07,;-5.61,2.56,;-4.53,3.65,;-4.92,5.14,;-3.04,3.25,;-2.64,1.76,;2.14,-3.6,;2.14,-5.14,;3.47,-2.83,)|

Structure