Ki Summary

Reaction Details

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Target

Carboxypeptidase B2

Ligand

BDBM109262

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Inhibition Assay

IC50

9.8±n/a nM

Citation

Nagata, T; Inoue, M; Ashida, Y; Noguchi, K; Ono, M Cycloalkyl-substituted imidazole derivative US Patent US8609710 Publication Date 12/17/2013

More Info.:

Get all data from this article, Assay Method

Carboxypeptidase B2

Name:

Carboxypeptidase B2

Synonyms:

Type:

Enzyme

Mol. Mass.:

48432.74

Organism:

Homo sapiens (Human)

Description:

Q96IY4

Residue:

423

Sequence:

MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV

BDBM109262

n/a

Name

BDBM109262

Synonyms:

US8609710, 38

Type

Small organic molecule

Emp. Form.

C20H28N4O3

Mol. Mass.

372.4613

SMILES

NCCCC(Cc1cn(cn1)[C@H]1CC[C@@H](CC1)Oc1ccncc1)C(O)=O |r,wU:11.11,wD:14.18,(5.63,1.13,;4.3,.36,;4.3,-1.18,;2.96,-1.95,;2.96,-3.49,;1.63,-4.26,;.29,-3.49,;.29,-1.95,;-1.17,-1.48,;-2.08,-2.72,;-1.17,-3.97,;-1.57,.01,;-3.06,.41,;-3.46,1.89,;-2.37,2.98,;-.88,2.58,;-.48,1.1,;-2.76,4.47,;-4.3,4.47,;-5.07,5.8,;-6.61,5.8,;-7.38,4.47,;-6.61,3.14,;-5.07,3.14,;4.3,-4.26,;4.3,-5.8,;5.63,-3.49,)|

Structure