Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK3 | ||
| Ligand | BDBM113083 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 163±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK3 | |||
| Name: | Tyrosine-protein kinase JAK3 | ||
| Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
| Type: | Protein | ||
| Mol. Mass.: | 125111.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P52333 | ||
| Residue: | 1124 | ||
| Sequence: |
| ||
| BDBM113083 | |||
| n/a | |||
| Name | BDBM113083 | ||
| Synonyms: | US8633206, 1 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H27N5O3S | ||
| Mol. Mass. | 393.504 | ||
| SMILES | CN(C1CC[C@H](CS(=O)(=O)N2CC[C@@H](O)C2)CC1)c1ncnc2[nH]ccc12 |r,wU:13.13,wD:5.5,(-6.62,.53,;-5.29,-.24,;-3.96,.53,;-3.96,2.07,;-2.62,2.84,;-1.29,2.07,;.05,2.84,;1.38,2.07,;.61,.74,;2.15,.74,;2.71,2.84,;2.71,4.38,;4.18,4.86,;5.08,3.61,;6.62,3.61,;4.18,2.37,;-1.29,.53,;-2.62,-.24,;-5.29,-1.78,;-6.62,-2.55,;-6.62,-4.09,;-5.29,-4.86,;-3.96,-4.09,;-2.49,-4.56,;-1.59,-3.32,;-2.49,-2.07,;-3.96,-2.55,)| | ||
| Structure | 
| ||