Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK3 | ||
| Ligand | BDBM113165 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 133±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK3 | |||
| Name: | Tyrosine-protein kinase JAK3 | ||
| Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
| Type: | Protein | ||
| Mol. Mass.: | 125111.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P52333 | ||
| Residue: | 1124 | ||
| Sequence: |
| ||
| BDBM113165 | |||
| n/a | |||
| Name | BDBM113165 | ||
| Synonyms: | US8633206, 83 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H35N5O4S2 | ||
| Mol. Mass. | 545.717 | ||
| SMILES | CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@H](C2)S(=O)(=O)CCc2ccccc2)CC1)c1ncnc2[nH]ccc12 |r,wU:5.5,13.15,wD:2.1,(8.52,-.82,;7.19,-1.59,;5.86,-.82,;5.86,.72,;4.52,1.49,;3.19,.72,;1.86,1.49,;.52,.72,;.52,-.82,;1.86,-.05,;-.81,1.49,;-.79,3.03,;-2.26,3.5,;-3.16,2.26,;-2.26,1.01,;-4.65,1.86,;-5.05,.37,;-6.14,1.46,;-5.74,2.95,;-7.23,2.55,;-8.32,3.64,;-7.92,5.12,;-9.01,6.21,;-10.5,5.82,;-10.89,4.33,;-9.81,3.24,;3.19,-.82,;4.52,-1.59,;7.19,-3.13,;5.86,-3.9,;5.86,-5.44,;7.19,-6.21,;8.52,-5.44,;9.99,-5.92,;10.89,-4.67,;9.99,-3.43,;8.52,-3.9,)| | ||
| Structure | 
| ||