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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK3 | ||
| Ligand | BDBM113191 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 289±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK3 | |||
| Name: | Tyrosine-protein kinase JAK3 | ||
| Synonyms: | JAK-3 | JAK3 | JAK3_HUMAN | Janus kinase 3 | Janus kinase 3 (JAK3) | Janus kinase 3 JAK3 | L-JAK | Leukocyte janus kinase | ||
| Type: | Protein | ||
| Mol. Mass.: | 125111.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P52333 | ||
| Residue: | 1124 | ||
| Sequence: |
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| BDBM113191 | |||
| n/a | |||
| Name | BDBM113191 | ||
| Synonyms: | US8633206, 109 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H25N5O2S | ||
| Mol. Mass. | 363.478 | ||
| SMILES | CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC2)CC1)c1ncnc2[nH]ccc12 |r,wU:5.5,wD:2.1,(4.43,.8,;3.09,.03,;1.76,.8,;1.76,2.34,;.43,3.11,;-.91,2.34,;-2.24,3.11,;-3.58,2.34,;-3.58,.8,;-2.24,1.57,;-4.91,3.11,;-5.31,4.59,;-6.8,4.2,;-6.4,2.71,;-.91,.8,;.43,.03,;3.09,-1.51,;1.76,-2.28,;1.76,-3.82,;3.09,-4.59,;4.43,-3.82,;5.89,-4.3,;6.8,-3.05,;5.89,-1.81,;4.43,-2.28,)| | ||
| Structure | 
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