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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM113124 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 66.9±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
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| BDBM113124 | |||
| n/a | |||
| Name | BDBM113124 | ||
| Synonyms: | US8633206, 42 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H28N6O2S | ||
| Mol. Mass. | 416.54 | ||
| SMILES | CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC(CC2)C#N)CC1)c1ncnc2[nH]ccc12 |r,wU:5.5,wD:2.1,(6.15,,;4.82,-.77,;3.48,,;3.48,1.54,;2.15,2.31,;.82,1.54,;-.52,2.31,;-1.85,1.54,;-1.85,,;-.52,.77,;-3.19,2.31,;-3.19,3.85,;-4.52,4.62,;-5.85,3.85,;-5.85,2.31,;-4.52,1.54,;-7.19,4.62,;-8.52,5.39,;.82,,;2.15,-.77,;4.82,-2.31,;3.48,-3.08,;3.48,-4.62,;4.82,-5.39,;6.15,-4.62,;7.61,-5.1,;8.52,-3.85,;7.61,-2.6,;6.15,-3.08,)| | ||
| Structure | 
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