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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM113129 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 68.4±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
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| BDBM113129 | |||
| n/a | |||
| Name | BDBM113129 | ||
| Synonyms: | US8633206, 47 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H35N5O3S | ||
| Mol. Mass. | 449.61 | ||
| SMILES | CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC(CC2)C(C)(C)O)CC1)c1ncnc2[nH]ccc12 |r,wU:5.5,wD:2.1,(6.15,-.39,;4.82,-1.16,;3.48,-.39,;3.48,1.15,;2.15,1.92,;.82,1.15,;-.52,1.93,;-1.85,1.15,;-1.85,-.38,;-.52,.38,;-3.19,1.93,;-3.19,3.47,;-4.52,4.23,;-5.85,3.47,;-5.85,1.93,;-4.52,1.15,;-7.19,4.24,;-7.19,5.78,;-8.52,5.01,;-8.52,3.47,;.82,-.39,;2.15,-1.15,;4.82,-2.7,;3.48,-3.47,;3.48,-5.01,;4.82,-5.78,;6.15,-5.01,;7.61,-5.48,;8.52,-4.24,;7.61,-2.99,;6.15,-3.47,)| | ||
| Structure | 
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