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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK2 | ||
| Ligand | BDBM113148 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 22±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK2 | |||
| Name: | Tyrosine-protein kinase JAK2 | ||
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | 130684.68 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O60674 | ||
| Residue: | 1132 | ||
| Sequence: |
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| BDBM113148 | |||
| n/a | |||
| Name | BDBM113148 | ||
| Synonyms: | US8633206, 66 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H32N6O4S2 | ||
| Mol. Mass. | 484.636 | ||
| SMILES | CN([C@H]1CC[C@H](CS(=O)(=O)N2CCC[C@H](CS(N)(=O)=O)C2)CC1)c1ncnc2[nH]ccc12 |r,wU:5.5,14.14,wD:2.1,(6.15,.38,;4.82,-.38,;3.48,.38,;3.48,1.93,;2.15,2.69,;.82,1.93,;-.52,2.69,;-1.85,1.93,;-1.85,.38,;-.52,1.15,;-3.19,2.69,;-3.19,4.23,;-4.52,5,;-5.85,4.23,;-5.85,2.69,;-7.19,1.93,;-7.19,.39,;-5.85,-.38,;-8.52,-.38,;-7.19,-1.15,;-4.52,1.93,;.82,.38,;2.15,-.38,;4.82,-1.93,;3.48,-2.69,;3.48,-4.23,;4.82,-5,;6.15,-4.23,;7.61,-4.71,;8.52,-3.47,;7.61,-2.22,;6.15,-2.69,)| | ||
| Structure | 
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