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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM113167 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzymatic Assay | ||
| pH | 7.4±n/a | ||
| IC50 | 10.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Promo, MA; Xie, J; Acker, BA; Hartmann, SJ; Wolfson, SG; Huang, H; Jacobsen, EJ Pyrrolo[2,3-D]pyrimidine compounds US Patent US8633206 Publication Date 1/21/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM113167 | |||
| n/a | |||
| Name | BDBM113167 | ||
| Synonyms: | US8633206, 85 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H34N6O4S | ||
| Mol. Mass. | 502.63 | ||
| SMILES | CN([C@H]1CC[C@H](CS(=O)(=O)N2CC[C@@](O)(CCc3cc(C)no3)C2)CC1)c1ncnc2[nH]ccc12 |r,wU:5.5,13.13,wD:2.1,13.14,(6.05,-2.8,;4.72,-3.57,;3.39,-2.8,;3.39,-1.26,;2.05,-.49,;.72,-1.26,;-.62,-.49,;-1.95,-1.26,;-1.95,-2.8,;-.62,-2.03,;-3.28,-.49,;-3.27,1.05,;-4.73,1.53,;-5.64,.28,;-6.41,-1.05,;-6.41,1.61,;-5.64,2.95,;-6.41,4.28,;-5.93,5.75,;-7.18,6.65,;-7.18,8.19,;-8.42,5.75,;-7.95,4.28,;-4.73,-.97,;.72,-2.8,;2.05,-3.57,;4.72,-5.11,;3.39,-5.88,;3.39,-7.42,;4.72,-8.19,;6.05,-7.42,;7.52,-7.9,;8.42,-6.65,;7.52,-5.4,;6.05,-5.88,)| | ||
| Structure | 
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