Ki Summary

Reaction Details

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Target

Disintegrin and metalloproteinase domain-containing protein 17

Ligand

BDBM50100

Substrate/Competitor

n/a

Meas. Tech.

Counterscreen for exosite inhibitors of ADAM10: QFRET-based biochemical high throughput dose response assay to identify inhibitors of ADAM17

IC50

33734±n/a nM

Citation

PubChem, PC Counterscreen for exosite inhibitors of ADAM10: QFRET-based biochemical high throughput dose response assay to identify inhibitors of ADAM17 PubChem Bioassay(2014)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Disintegrin and metalloproteinase domain-containing protein 17

Name:

Disintegrin and metalloproteinase domain-containing protein 17

Synonyms:

Type:

Enzyme

Mol. Mass.:

93007.89

Organism:

Homo sapiens (Human)

Description:

Residue:

824

Sequence:

MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV
GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM
AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC
KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD
PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC

BDBM50100

n/a

Name

BDBM50100

Synonyms:

(5E)-5-[[4-(4-methylphenyl)-2-thiophen-2-yl-4H-1-benzopyran-3-yl]methylidene]-2-sulfanylidene-4-thiazolidinone | (5E)-5-[[4-(4-methylphenyl)-2-thiophen-2-yl-4H-chromen-3-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | (5E)-5-[[4-(p-tolyl)-2-(2-thienyl)-4H-chromen-3-yl]methylene]-2-thioxo-thiazolidin-4-one | 5-[1-(2-Thiophen-2-yl-4-p-tolyl-4H-chromen-3-yl)-meth-(E)-ylidene]-2-thioxo-thiazolidin-4-one | MLS000595348 | SMR000149871 | cid_9551861

Type

Small organic molecule

Emp. Form.

C24H17NO2S3

Mol. Mass.

447.592

SMILES

Cc1ccc(cc1)C1C(C=C2SC(S)=NC2=O)=C(Oc2ccccc12)c1cccs1 |w:9.9,c:14,18,(11.05,-6.19,;11.05,-4.65,;9.72,-3.88,;9.72,-2.34,;11.05,-1.57,;12.38,-2.34,;12.38,-3.88,;11.05,-.03,;9.72,.74,;8.38,-.03,;7.05,.74,;5.64,.11,;4.61,1.26,;3.08,1.1,;5.38,2.59,;6.89,2.27,;8.03,3.3,;9.72,2.28,;11.05,3.05,;12.38,2.28,;13.76,3.1,;15.16,2.31,;15.16,.71,;13.76,-.08,;12.38,.74,;9.72,3.82,;10.96,4.73,;10.49,6.19,;8.95,6.19,;8.47,4.73,)|

Structure