| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 2 |
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| Ligand | BDBM64030 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) |
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| IC50 | 1273±n/a nM |
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| Citation |  PubChem, PC Epi Absorbance-based biochemical high throughput dose response assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) PubChem Bioassay(2014)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Tyrosyl-DNA phosphodiesterase 2 |
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| Name: | Tyrosyl-DNA phosphodiesterase 2 |
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| Synonyms: | EAP2 | EAPII | ETS1-associated protein 2 | ETS1-associated protein II | TDP2 | TRAF and TNF receptor-associated protein | TTRAP | TYDP2_HUMAN | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 (hTDP2) | Tyrosyl-RNA phosphodiesterase | VPg unlinkase | hTDP2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40916.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_23510348 |
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| Residue: | 362 |
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| Sequence: | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNS
YFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWN
IDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFT
AIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQ
LKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQ
MNSNLGITAACKLRFDRIFFRAAAEEGHIIPRSLDLLGLEKLDCGRFPSDHWGLLCNLDI
IL
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|
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| BDBM64030 |
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| n/a |
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| Name | BDBM64030 |
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| Synonyms: | 3-Amino-6,6-dimethyl-2-phenyl-2,8-dihydro-6H-pyrano[3,4-c]pyridazine-4-carbonitrile | 3-amino-6,6-dimethyl-2-phenyl-8H-pyrano[3,4-c]pyridazine-4-carbonitrile | 3-azanyl-6,6-dimethyl-2-phenyl-8H-pyrano[3,4-c]pyridazine-4-carbonitrile | MLS001205950 | SMR000513314 | cid_738951 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N4O |
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| Mol. Mass. | 280.3244 |
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| SMILES | CC1(C)Cc2c(CO1)nn(-c1ccccc1)c(=N)c2C#N |
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| Structure | 
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