| Reaction Details |
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 | Report a problem with these data |
| Target | Urea transporter 1 |
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| Ligand | BDBM115184 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | UT-B Inhibition Assay |
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| IC50 | 6.2e+3±n/a nM |
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| Citation |  Esteva-Font, C; Phuan, PW; Anderson, MO; Verkman, AS A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol20:1235-44 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urea transporter 1 |
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| Name: | Urea transporter 1 |
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| Synonyms: | Slc14a1 | UT11 | UT1_RAT | UT3 | Urea transporter B (UT-B) |
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| Type: | Protein |
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| Mol. Mass.: | 42037.85 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | n/a |
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| Residue: | 384 |
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| Sequence: | MEDIPTMVKVDRGESQILSCRGRRCGLKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRG
ISQVVFVSNPISGILILAGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYN
ATLVGILMAVFSDKGDYFWWLIFPVSAMSMTCPVFSSALSSLFSKWDLPVFTLPFNMALS
LYLSATGHYNTFFPSKLFMPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGAIF
LCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFKDIYSGLWGFNSSLACIAIGGMFMALT
WQTHLLALACALFTAYFGACMTHLMAAVHLPACTWSFCLATLLFLLLTTENPNIYRMPLS
KVTYSEENRIFYLQNKKRVVDSPL
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| BDBM115184 |
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| n/a |
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| Name | BDBM115184 |
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| Synonyms: | 8‐methoxy‐N‐(4‐methoxyphenyl)‐2‐(thiomorpholine‐4‐ carbonyl)quinolin‐4‐amine | UT-A1 inhibitor A3 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N3O3S |
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| Mol. Mass. | 409.501 |
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| SMILES | COc1ccc(Nc2cc(nc3c(OC)cccc23)C(=O)N2CCSCC2)cc1 |
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| Structure | 
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