Reaction Details |
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Target | Nociceptin receptor |
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Ligand | BDBM116225 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ORL-1 Receptor Binding Assay |
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pH | 7.4±n/a |
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Temperature | 277.15±n/a K |
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Ki | 68±n/a nM |
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Comments | extracted |
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Citation | Brown, KC; Goehring, RR 2,3,4,5-tetrahydro-benzo{B}{1,4}diazepine-comprising compounds of formula(III) for treating pain US Patent US8637502 Publication Date 1/28/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Nociceptin receptor |
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Name: | Nociceptin receptor |
Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40702.87 |
Organism: | Homo sapiens (Human) |
Description: | P41146 |
Residue: | 370 |
Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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BDBM116225 |
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n/a |
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Name | BDBM116225 |
Synonyms: | US8637502, 87 |
Type | Small organic molecule |
Emp. Form. | C24H32FN3O4 |
Mol. Mass. | 445.527 |
SMILES | COC(=O)C1(CCCCCCC1)N1CCC(CC1)N1c2cc(F)ccc2NC(=O)CC1=O |
Structure |
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