| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM123786 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Selectivity |
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| IC50 | 454± 57 nM |
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| Citation |  Jorda, R; Navratilova, J; Huskova, Z; Schutznerova, E; Cankai, P; Strnad, M; Krystof, V Arylazopyrazole AAP1742 inhibits CDKs and induces apoptosis in multiple myeloma cells via Mcl-1 downregulation. Chem Biol Drug Des84:402-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM123786 |
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| n/a |
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| Name | BDBM123786 |
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| Synonyms: | AAP1742 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H9N7 |
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| Mol. Mass. | 203.204 |
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| SMILES | Nc1n[nH]c(N)c1\N=N\c1ccncc1 |
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| Structure | 
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