| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
|---|
| Ligand | BDBM38550 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Cyclooxygenase (COX) Inhibition Assay |
|---|
| Temperature | 310.15±0 K |
|---|
| IC50 | >1.00e+5±n/a nM |
|---|
| Citation |  Dube, PN; Bule, SS; Mokale, SN; Kumbhare, MR; Dighe, PR; Ushir, YV Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivatives as selective COX-2 inhibitors: molecular docking study. Chem Biol Drug Des84:409-19 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 1 |
|---|
| Name: | Prostaglandin G/H synthase 1 |
|---|
| Synonyms: | COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68868.60 |
|---|
| Organism: | Ovis aries (Sheep) |
|---|
| Description: | n/a |
|---|
| Residue: | 600 |
|---|
| Sequence: | MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCT
RTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVR
SNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRR
FLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLER
QYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLML
YATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLK
FDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVE
ALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQE
LTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPIC
SPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
|
|
|
|---|
| BDBM38550 |
|---|
| n/a |
|---|
| Name | BDBM38550 |
|---|
| Synonyms: | 3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE | 5-methyl-2-phenyl-1,2- dihydro-3H-pyrazol-3-one (3) | 5-methyl-2-phenyl-2-pyrazolin-3-one | 5-methyl-2-phenyl-4H-pyrazol-3-one | MLS000069602 | SMR000059020 | cid_4021 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H10N2O |
|---|
| Mol. Mass. | 174.1992 |
|---|
| SMILES | Cc1cc(=O)n([nH]1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
