Reaction Details | |||
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Target | Mitogen-activated protein kinase 14 | ||
Ligand | BDBM125996 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.8±n/a nM | ||
Citation | Eastwood, PR; Gonzalez Rodriguez, J; Vidal Juan, B; Aguilar Izquierdo, N Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors US Patent US8772288 Publication Date 7/8/2014 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Mitogen-activated protein kinase 14 | |||
Name: | Mitogen-activated protein kinase 14 | ||
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 41286.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16539 | ||
Residue: | 360 | ||
Sequence: |
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BDBM125996 | |||
n/a | |||
Name | BDBM125996 | ||
Synonyms: | US8772288, 37 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H28N2O3 | ||
Mol. Mass. | 404.5014 | ||
SMILES | Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCC(C)(O)CC2)c1)C(=O)NC1CC1 |(-4.1,1.56,;-2.77,2.33,;-2.77,3.87,;-1.44,4.64,;-.1,3.87,;-.1,2.33,;-1.44,1.56,;-1.44,.02,;-.1,-.75,;-.1,-2.29,;-1.44,-3.06,;-2.77,-2.29,;-3.91,-3.32,;-3.29,-4.73,;-4.06,-6.06,;-1.76,-4.57,;-2.16,-6.05,;-1.07,-7.14,;.42,-6.74,;.42,-8.28,;1.91,-7.14,;.82,-5.26,;-.27,-4.17,;-2.77,-.75,;1.23,4.64,;2.56,3.87,;1.23,6.18,;2.56,6.95,;4.1,6.95,;3.33,8.28,)| | ||
Structure |