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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM125997 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1±n/a nM | ||
| Citation |  Eastwood, PR; Gonzalez Rodriguez, J; Vidal Juan, B; Aguilar Izquierdo, N Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors US Patent US8772288 Publication Date 7/8/2014 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM125997 | |||
| n/a | |||
| Name | BDBM125997 | ||
| Synonyms: | US8772288, 40 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H33N3O3 | ||
| Mol. Mass. | 459.5799 | ||
| SMILES | Cc1ccc(cc1-c1ccc2c(NC(=O)C22CCC(CC2)N2CCOCC2)c1)C(=O)NC1CC1 |(-4.77,3.67,;-3.44,4.44,;-3.44,5.98,;-2.1,6.75,;-.77,5.98,;-.77,4.44,;-2.1,3.67,;-2.1,2.13,;-.77,1.36,;-.77,-.18,;-2.1,-.95,;-3.44,-.18,;-4.58,-1.21,;-3.96,-2.61,;-4.73,-3.95,;-2.42,-2.45,;-2.82,-3.94,;-1.73,-5.03,;-.25,-4.63,;.15,-3.14,;-.94,-2.05,;.84,-5.72,;.44,-7.21,;1.53,-8.29,;3.02,-7.9,;3.42,-6.41,;2.33,-5.32,;-3.44,1.36,;.56,6.75,;.56,8.29,;1.9,5.98,;3.23,6.75,;4,8.09,;4.77,6.75,)| | ||
| Structure | 
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