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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM126000 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.5±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 8±n/a nM | ||
| Citation |  Eastwood, PR; Gonzalez Rodriguez, J; Vidal Juan, B; Aguilar Izquierdo, N Substituted spiro[cycloalkyl-1,3′-indo]-2′(1′H)-one derivatives and their use as P38 mitogen-activated kinase inhibitors US Patent US8772288 Publication Date 7/8/2014 | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
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| BDBM126000 | |||
| n/a | |||
| Name | BDBM126000 | ||
| Synonyms: | US8772288, 65 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25FN4O2 | ||
| Mol. Mass. | 420.4793 | ||
| SMILES | Cc1nnc([nH]1)-c1cc(F)c(C)c(c1)-c1ccc2c(NC(=O)C22CCC(C)(O)CC2)c1 |(3.72,8.14,;2.95,6.8,;3.85,5.56,;2.95,4.31,;1.48,4.79,;1.48,6.33,;.15,4.02,;-1.18,4.79,;-2.52,4.02,;-3.85,4.79,;-2.52,2.48,;-3.85,1.71,;-1.18,1.71,;.15,2.48,;-1.18,.17,;.15,-.6,;.15,-2.14,;-1.18,-2.91,;-2.52,-2.14,;-3.66,-3.17,;-3.04,-4.58,;-3.81,-5.91,;-1.51,-4.42,;-1.9,-5.91,;-.81,-7,;.67,-6.6,;.67,-8.14,;2.01,-7.37,;1.07,-5.11,;-.02,-4.02,;-2.52,-.6,)| | ||
| Structure | 
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