| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinate-nucleotide adenylyltransferase |
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| Ligand | BDBM50318653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 65000±n/a nM |
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| Comments | extracted |
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| Citation |  Mackerell, Jr., A; Zhang, H; Osterman, A; Kolhatkar, R Targeting NAD biosynthesis in bacterial pathogens US Patent US8785499 Publication Date 7/22/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Nicotinate-nucleotide adenylyltransferase |
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| Name: | Nicotinate-nucleotide adenylyltransferase |
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| Synonyms: | Deamido-NAD(+) pyrophosphorylase | NADD_ECOLI | Nicotinate mononucleotide adenylyltransferase (NadD) | Nicotinate-nucleotide adenylyltransferase (NadD) | nadD | ybeN |
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| Type: | Enzyme |
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| Mol. Mass.: | 24523.61 |
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| Organism: | Escherichia coli |
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| Description: | P0A752 |
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| Residue: | 213 |
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| Sequence: | MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHML
ELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEY
ETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNIS
ATIIRERLQNGESCEDLLPEPVLTYINQQGLYR
|
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|
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| BDBM50318653 |
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| n/a |
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| Name | BDBM50318653 |
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| Synonyms: | 3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxamide | 3-amino-N-(3-fluorophenyl)-6-thiophen-2-ylthieno[2,3-b]pyridine-2-carboxamide | CHEMBL1084955 | NadD inhibitor 3_02 | US8785499, 3_02 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H12FN3OS2 |
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| Mol. Mass. | 369.436 |
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| SMILES | Nc1c(sc2nc(ccc12)-c1cccs1)C(=O)Nc1cccc(F)c1 |
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| Structure | 
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