Reaction Details |
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Target | Tyrosine-protein kinase SYK |
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Ligand | BDBM127948 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay |
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pH | 7.5±n/a |
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IC50 | 0.67±n/a nM |
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Comments | extracted |
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Citation | Romeo, ET; Machacek, MR; Trotter, BW; Miller, TA; Andresen, BM; Anthony, NJ; Taoka, BM; Liu, Y Amino-pyridine-containing spleen tyrosine kinase (SYK) inhibitors US Patent US8796310 Publication Date 8/5/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase SYK |
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Name: | Tyrosine-protein kinase SYK |
Synonyms: | KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk) |
Type: | Enzyme |
Mol. Mass.: | 72079.99 |
Organism: | Homo sapiens (Human) |
Description: | P43405 |
Residue: | 635 |
Sequence: | MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK
PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
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BDBM127948 |
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n/a |
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Name | BDBM127948 |
Synonyms: | US8796310, 1o |
Type | Small organic molecule |
Emp. Form. | C30H30N4O4S |
Mol. Mass. | 542.649 |
SMILES | Cc1cc(Nc2cc(OC3CCCC3)ccn2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O |
Structure |
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