Reaction Details |
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Target | Chymase |
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Ligand | BDBM134267 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibitory Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 3±n/a nM |
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Comments | extracted |
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Citation | Muto, T; Tanaka, T; Futamura, J; Imajo, S; Sugawara, H Seven-membered ring compound and pharmaceutical use therefor US Patent US8846660 Publication Date 9/30/2014 |
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More Info.: | Get all data from this article, Assay Method |
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Chymase |
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Name: | Chymase |
Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
Type: | Enzyme |
Mol. Mass.: | 27340.12 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 247 |
Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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BDBM134267 |
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n/a |
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Name | BDBM134267 |
Synonyms: | US8846660, 41 |
Type | Small organic molecule |
Emp. Form. | C30H29ClF2N4O6 |
Mol. Mass. | 615.024 |
SMILES | COc1ccc(Cl)cc1CC1CN\C(CN(C(=O)N[C@H](C)c2ccc(CC(O)=O)cc2)C1=O)=N/Oc1cc(F)cc(F)c1 |r| |
Structure |
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