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TargetDNA gyrase subunit A
LigandBDBM139401
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarisation Assay
pH7.5±n/a
IC50 420±n/a nM
Commentsextracted
Citation Basarab, GS; Gowravaram, MR; Hauck, SI; Zhou, F Compounds and methods for treating bacterial infections US Patent US8889671 Publication Date 11/18/2014
More Info.:Get all data from this article,  Assay Method
 
DNA gyrase subunit A
Name:DNA gyrase subunit A
Synonyms:DNA gyrase | DNA gyrase subunit A (gyrA) | GYRA_ECOLI | gyrA | hisW | nalA | parD
Type:Enzyme Subunit
Mol. Mass.:96935.15
Organism:Escherichia coli (strain K12)
Description:n/a
Residue:875
Sequence:
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWN
KAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
RYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMAT
NIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKV
YIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG
MRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRRE
VVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNV
AAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVV
VTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVY
SMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVL
TEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTG
VRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERN
GLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVA
EPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE
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  Blast E-value cutoff:
BDBM139401
n/a
NameBDBM139401
Synonyms:US8889671, 31
TypeSmall organic molecule
Emp. Form.C23H24FN5O8
Mol. Mass.517.4638
SMILESC[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(noc4c(F)c23)N2[C@@H](CCO)COC2=O)C(=O)NC(=O)NC1=O |r|
Structure
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