Ki Summary

Reaction Details

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Target

C-C chemokine receptor type 2

Ligand

BDBM141920

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

Temperature

310.15±n/a K

IC50

75±n/a nM

Comments

extracted

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z; Zhang, X 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2 US Patent US8921559 Publication Date 12/30/2014

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor type 2

Name:

C-C chemokine receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41932.32

Organism:

Homo sapiens (Human)

Description:

P41597

Residue:

374

Sequence:

MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA

BDBM141920

n/a

Name

BDBM141920

Synonyms:

US8921559, 10

Type

Small organic molecule

Emp. Form.

C31H35F3N4O2

Mol. Mass.

552.6304

SMILES

NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)\C=C\c1cccc(c1)C(F)(F)F |(-1.61,1.22,;-2.95,.44,;-4.28,1.22,;-2.95,-1.09,;-4.28,-1.87,;-5.61,-1.09,;-6.95,-1.87,;-8.28,-1.09,;-8.28,.44,;-6.95,1.22,;-5.61,.44,;-9.61,1.22,;-11.08,.74,;-11.98,1.98,;-11.08,3.23,;-11.4,4.74,;-10.25,5.77,;-8.79,5.29,;-8.47,3.79,;-9.61,2.75,;-1.61,-1.87,;-1.61,-3.4,;-.28,-4.17,;1.06,-3.4,;1.06,-1.87,;-.28,-1.09,;2.39,-4.17,;2.39,-5.71,;3.72,-3.4,;5.06,-4.17,;6.39,-3.4,;6.39,-1.87,;7.72,-1.09,;9.06,-1.87,;9.17,-3.48,;7.72,-4.17,;10.5,-4.26,;11.83,-5.03,;9.73,-5.59,;11.28,-2.93,)|

Structure