Ki Summary

Reaction Details

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Target

C-C chemokine receptor type 2

Ligand

BDBM141924

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

Temperature

310.15±n/a K

IC50

150±n/a nM

Comments

extracted

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z; Zhang, X 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2 US Patent US8921559 Publication Date 12/30/2014

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor type 2

Name:

C-C chemokine receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41932.32

Organism:

Homo sapiens (Human)

Description:

P41597

Residue:

374

Sequence:

MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA

BDBM141924

n/a

Name

BDBM141924

Synonyms:

US8921559, 16

Type

Small organic molecule

Emp. Form.

C29H34F3N5O2

Mol. Mass.

541.6078

SMILES

NC(=O)C(NC1CCC(CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)Nc1cccc(c1)C(F)(F)F |(-.82,1.57,;-2.15,.8,;-3.48,1.57,;-2.15,-.74,;-3.48,-1.51,;-4.82,-.74,;-6.15,-1.51,;-7.48,-.74,;-7.48,.8,;-6.15,1.57,;-4.82,.8,;-8.82,1.57,;-10.28,1.1,;-11.19,2.34,;-10.28,3.59,;-10.6,5.1,;-9.46,6.13,;-7.99,5.65,;-7.67,4.14,;-8.82,3.11,;-.82,-1.51,;-.82,-3.05,;.52,-3.82,;1.85,-3.05,;1.85,-1.51,;.52,-.74,;3.19,-3.82,;3.19,-5.36,;4.52,-3.05,;5.85,-3.82,;5.85,-5.36,;7.19,-6.13,;8.52,-5.36,;8.52,-3.82,;7.19,-3.05,;9.85,-3.05,;11.19,-3.82,;9.85,-1.51,;11.19,-2.28,)|

Structure