Ki Summary

Reaction Details

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Target

C-C chemokine receptor type 2

Ligand

BDBM141934

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

Temperature

310.15±n/a K

IC50

230±n/a nM

Comments

extracted

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z; Zhang, X 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2 US Patent US8921559 Publication Date 12/30/2014

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor type 2

Name:

C-C chemokine receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41932.32

Organism:

Homo sapiens (Human)

Description:

P41597

Residue:

374

Sequence:

MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA

BDBM141934

n/a

Name

BDBM141934

Synonyms:

US8921559, 27

Type

Small organic molecule

Emp. Form.

C28H32Cl2N4O3

Mol. Mass.

543.485

SMILES

OC(=O)C(N[C@H]1CC[C@@H](CC1)c1c[nH]c2ccccc12)C1CCN(CC1)C(=O)Nc1ccc(Cl)c(Cl)c1 |r,wU:5.4,wD:8.11,(-.13,1.59,;-1.46,.82,;-2.8,1.59,;-1.46,-.72,;-2.8,-1.49,;-4.13,-.72,;-5.47,-1.49,;-6.8,-.72,;-6.8,.82,;-5.47,1.59,;-4.13,.82,;-8.13,1.59,;-9.57,1.04,;-10.54,2.24,;-9.7,3.53,;-10.1,5.02,;-9.01,6.11,;-7.52,5.71,;-7.12,4.22,;-8.21,3.13,;-.13,-1.49,;-.13,-3.03,;1.2,-3.8,;2.54,-3.03,;2.54,-1.49,;1.2,-.72,;3.87,-3.8,;3.87,-5.34,;5.2,-3.03,;6.54,-3.8,;6.54,-5.34,;7.87,-6.11,;9.21,-5.34,;10.54,-6.11,;9.21,-3.8,;10.54,-3.03,;7.87,-3.03,)|

Structure