Ki Summary

Reaction Details

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Target

C-C chemokine receptor type 2

Ligand

BDBM141947

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

Temperature

310.15±n/a K

IC50

87±n/a nM

Comments

extracted

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z; Zhang, X 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2 US Patent US8921559 Publication Date 12/30/2014

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor type 2

Name:

C-C chemokine receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41932.32

Organism:

Homo sapiens (Human)

Description:

P41597

Residue:

374

Sequence:

MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA

BDBM141947

n/a

Name

BDBM141947

Synonyms:

US8921559, 42

Type

Small organic molecule

Emp. Form.

C27H32Cl2N6O2

Mol. Mass.

543.488

SMILES

NC(=O)C(NC1CCC(CC1)c1c[nH]c2cccnc12)C1CCN(CC1)C(=O)Nc1ccc(Cl)c(Cl)c1 |(-.15,1.57,;-1.48,.8,;-2.82,1.57,;-1.48,-.74,;-2.82,-1.51,;-4.15,-.74,;-5.48,-1.51,;-6.82,-.74,;-6.82,.8,;-5.48,1.57,;-4.15,.8,;-8.15,1.57,;-9.62,1.1,;-10.52,2.34,;-9.62,3.59,;-9.94,5.1,;-8.79,6.13,;-7.33,5.65,;-7.01,4.14,;-8.15,3.11,;-.15,-1.51,;1.18,-.74,;2.52,-1.51,;2.52,-3.05,;1.18,-3.82,;-.15,-3.05,;3.85,-3.82,;3.85,-5.36,;5.19,-3.05,;6.52,-3.82,;6.52,-5.36,;7.85,-6.13,;9.19,-5.36,;10.52,-6.13,;9.19,-3.82,;10.52,-3.05,;7.85,-3.05,)|

Structure