Ki Summary

Reaction Details

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Target

C-C chemokine receptor type 2

Ligand

BDBM141949

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

Temperature

310.15±n/a K

IC50

132±n/a nM

Comments

extracted

Citation

Lanter, JC; Markotan, TP; Subasinghe, N; Sui, Z; Zhang, X 4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2 US Patent US8921559 Publication Date 12/30/2014

More Info.:

Get all data from this article, Assay Method

C-C chemokine receptor type 2

Name:

C-C chemokine receptor type 2

Synonyms:

Type:

Enzyme

Mol. Mass.:

41932.32

Organism:

Homo sapiens (Human)

Description:

P41597

Residue:

374

Sequence:

MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA

BDBM141949

n/a

Name

BDBM141949

Synonyms:

US8921559, 44

Type

Small organic molecule

Emp. Form.

C29H32F3N5O2

Mol. Mass.

539.5919

SMILES

NC(=O)C(NC1CCC(CC1)c1c[nH]c2ncccc12)C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1 |(-.82,1.19,;-2.15,.42,;-3.48,1.19,;-2.15,-1.12,;-3.48,-1.89,;-4.82,-1.12,;-6.15,-1.89,;-7.48,-1.12,;-7.48,.42,;-6.15,1.19,;-4.82,.42,;-8.82,1.19,;-10.28,.71,;-11.19,1.96,;-10.28,3.2,;-10.6,4.71,;-9.46,5.74,;-7.99,5.27,;-7.67,3.76,;-8.82,2.73,;-.82,-1.89,;.52,-1.12,;1.85,-1.89,;1.85,-3.43,;.52,-4.2,;-.82,-3.43,;3.19,-4.2,;3.19,-5.74,;4.52,-3.43,;5.85,-4.2,;7.19,-3.43,;7.19,-1.89,;8.52,-1.12,;8.52,.42,;9.85,-1.89,;11.19,-1.12,;9.85,-3.43,;11.19,-4.2,;8.52,-4.2,)|

Structure