Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase receptor

Ligand

BDBM144299

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

IC50

0.21±n/a nM

Citation

Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent US8969336 Publication Date 3/3/2015

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase receptor

Name:

Tyrosine-protein kinase receptor

Synonyms:

EML4 ALK Fusion Protein

Type:

Protein

Mol. Mass.:

87656.33

Organism:

Homo sapiens (Human)

Description:

A9YLN7

Residue:

796

Sequence:

MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA
SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKE
KPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQ
ELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGH
GAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIG
VSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENH
FIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEG
IFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQ
CWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPL
LVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSN
PPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPN
VATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHY
EDTILKSKNSMNQPGP

BDBM144299

n/a

Name

BDBM144299

Synonyms:

US8969336, 392

Type

Small organic molecule

Emp. Form.

C31H48N8O2

Mol. Mass.

564.7652

SMILES

CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(CC3)N3CCN(C)CC3)c(C)c2)nc1N[C@H]1CC[C@@](C)(O)CC1 |r,wU:36.40,wD:33.36,36.41,(-2.38,6.54,;-2.38,5,;-1.05,4.23,;.29,5,;1.62,4.23,;2.96,5,;4.29,4.23,;2.96,6.54,;1.62,2.69,;2.96,1.92,;2.96,.38,;4.29,-.39,;4.29,-1.93,;2.96,-2.7,;2.96,-4.24,;4.29,-5.01,;4.29,-6.55,;2.96,-7.32,;1.62,-6.55,;1.62,-5.01,;2.96,-8.86,;4.29,-9.63,;4.29,-11.17,;2.96,-11.94,;2.96,-13.48,;1.62,-11.17,;1.62,-9.63,;1.62,-1.93,;.29,-2.7,;1.62,-.39,;.29,1.92,;-1.05,2.69,;-2.38,1.92,;-3.71,2.69,;-3.71,4.23,;-5.05,5,;-6.38,4.23,;-7.2,5.53,;-7.92,4.28,;-6.38,2.69,;-5.05,1.92,)|

Structure