Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase receptor

Ligand

BDBM144300

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

IC50

0.94±n/a nM

Citation

Shimada, I; Kurosawa, K; Matsuya, T; Iikubo, K; Kondoh, Y; Kamikawa, A; Tomiyama, H; Iwai, Y Diamino heterocyclic carboxamide compound US Patent US8969336 Publication Date 3/3/2015

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase receptor

Name:

Tyrosine-protein kinase receptor

Synonyms:

EML4 ALK Fusion Protein

Type:

Protein

Mol. Mass.:

87656.33

Organism:

Homo sapiens (Human)

Description:

A9YLN7

Residue:

796

Sequence:

MDGFAGSLDDSISAASTSDVQDRLSALESRVQQQEDEITVLKAALADVLRRLAISEDHVA
SVKKSVSSKGQPSPRAVIPMSCITNGSGANRKPSHTSAVSIAGKETLSSAAKSGTEKKKE
KPQGQREKKEESHSNDQSPQIRASPSPQPSSQPLQIHRQTPESKNATPTKSIKRPSPAEK
SHNSWENSDDSRNKLSKIPSTPKLIPKVTKTADKHKDVIINQAKMSTREKNSQVYRRKHQ
ELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGH
GAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIG
VSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENH
FIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEG
IFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQ
CWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPL
LVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSN
PPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPN
VATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHY
EDTILKSKNSMNQPGP

BDBM144300

n/a

Name

BDBM144300

Synonyms:

US8969336, 399

Type

Small organic molecule

Emp. Form.

C27H36F3N7O2

Mol. Mass.

547.6156

SMILES

CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(CC3)C3CC3)c(c2)C(F)(F)F)nc1N[C@H]1CC[C@H](O)CC1 |r,wU:32.35,wD:35.39,(5.38,1.95,;5.38,.41,;4.05,-.36,;2.67,.38,;1.33,-.38,;.56,.95,;1.33,2.28,;-.98,.95,;1.33,-1.93,;,-2.69,;-1.33,-1.93,;-1.33,-.38,;-2.67,.38,;-4,-.38,;-5.33,.38,;-5.33,1.93,;-6.67,2.69,;-8,1.93,;-8,.38,;-6.67,-.38,;-9.34,2.69,;-9.73,4.18,;-10.82,2.3,;-4.05,-1.95,;-2.67,-2.69,;-5.38,-2.72,;-6.72,-3.49,;-4.61,-4.06,;-6.15,-1.39,;2.67,-2.69,;4,-1.93,;5.33,-2.69,;6.67,-1.93,;6.67,-.38,;8,.38,;9.34,-.38,;10.67,.38,;9.34,-1.93,;8,-2.69,)|

Structure