Ki Summary

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Target

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Ligand

BDBM144664

Substrate/Competitor

n/a

Meas. Tech.

IMAP TR-FRET Assay

Temperature

298.15±n/a K

IC50

5.43±n/a nM

Comments

extracted

Citation

Allen, JR; Frohn, MJ; Harrington, PE; Hu, E; Pickrell, AJ; Rzasa, RM; Sham, KK Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors US Patent US8952037 Publication Date 2/10/2015

More Info.:

Get all data from this article, Assay Method

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Name:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Synonyms:

Type:

Protein

Mol. Mass.:

88412.52

Organism:

Homo sapiens (Human)

Description:

Q9Y233

Residue:

1055

Sequence:

MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED

BDBM144664

n/a

Name

BDBM144664

Synonyms:

US8952037, 37

Type

Small organic molecule

Emp. Form.

C21H21F2N3O2S

Mol. Mass.

417.472

SMILES

Fc1cnc(O[C@@H]2C[C@@H](C2)Nc2nc3c(F)cccc3s2)c(c1)C1CCOCC1 |r,wD:6.5,8.10,(-7.98,-3.85,;-6.65,-3.08,;-5.32,-3.85,;-3.98,-3.08,;-3.98,-1.54,;-2.65,-.77,;-1.32,-1.54,;.17,-1.14,;.57,-2.63,;-.92,-3.03,;1.9,-3.4,;3.24,-2.63,;3.4,-1.1,;4.9,-.78,;5.67,.56,;4.9,1.89,;7.21,.56,;7.98,-.78,;7.21,-2.11,;5.67,-2.11,;4.64,-3.26,;-5.32,-.77,;-6.65,-1.54,;-5.32,.77,;-6.65,1.54,;-6.65,3.08,;-5.32,3.85,;-3.98,3.08,;-3.98,1.54,)|

Structure