Ki Summary

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Target

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Ligand

BDBM144672

Substrate/Competitor

n/a

Meas. Tech.

IMAP TR-FRET Assay

Temperature

298.15±n/a K

IC50

4.11±n/a nM

Comments

extracted

Citation

Allen, JR; Frohn, MJ; Harrington, PE; Hu, E; Pickrell, AJ; Rzasa, RM; Sham, KK Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors US Patent US8952037 Publication Date 2/10/2015

More Info.:

Get all data from this article, Assay Method

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Name:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Synonyms:

Type:

Protein

Mol. Mass.:

88412.52

Organism:

Homo sapiens (Human)

Description:

Q9Y233

Residue:

1055

Sequence:

MASLEEPLAPRPQGPLPAAGDEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE
RAAPPRPPLSSAGRPSPAGGPGALSARGGGCGWVAARAPLALAFSSRVPSSSPSFFYFWP
PPPPPPPSFLPSSSAFHLPVRLPGREGAAAAAAAGGGGDAGGGGGGGQEAAPLSVPTSSS
HRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLGQAARRAGSPGFPGAGPGG
GGQTPRRPQGASFALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLS
LHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQ
RLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGP
ITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGIL
ELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNI
VAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRF
SIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQM
VNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSE
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMS
VKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSY
LQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATD
LALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYA
EFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKA
CRDNLSQWEKVIRGEETATWISSPSVAQKAAASED

BDBM144672

n/a

Name

BDBM144672

Synonyms:

US8952037, 45

Type

Small organic molecule

Emp. Form.

C21H19N5O2S

Mol. Mass.

405.473

SMILES

COc1ncccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:15.16,17.21,(-8.65,1.54,;-7.32,.77,;-5.98,1.54,;-5.98,3.08,;-4.65,3.85,;-3.32,3.08,;-3.32,1.54,;-4.65,.77,;-4.65,-.77,;-5.98,-1.54,;-5.98,-3.08,;-4.65,-3.85,;-3.32,-3.08,;-3.32,-1.54,;-1.98,-.77,;-.65,-1.54,;-.25,-3.03,;1.24,-2.63,;.84,-1.14,;2.57,-3.4,;3.9,-2.63,;4.07,-1.1,;5.57,-.78,;6.34,.56,;7.88,.56,;8.65,-.78,;7.88,-2.11,;6.34,-2.11,;5.31,-3.26,)|

Structure